Cholecystokinin Links To Anxiety-Panic Disorder – Mad Chaos: July 3, 2004

Latest Biorhythm Cycle Trends

Thank the overall transformation of my biorhythmic landscape, as ever since the first day of this month, where I had weathered a critical emotional day, an overcast sky has cleared to now allow mostly sunny days.  I am at an intellectual and intuitive minimum but I also have a physical maximum and emotional sunshine that will peak in five days, which means my passion rhythms are in the upper echelons.  

I feel like I have turned the corner to constructive momentum, which will be aided by an assisted endorphin release later.  I feel the wisdom rhythm (that are my emotional and intellectual sine values combined) has culminated to where I am now able to inch back into simpler revisions.  So, I will dedicate the next four or so hours to contemporary revisions before social commitments take precedence to assist an endorphin release.

Days where entries open in earlier afternoon hours are rare to a nocturnal creature like me.  I prefer to record my observational remarks as a sedative before sleep.  In this case, where my emotional manner has turned a corner, and because a social function requires me later today, a break of protocol is essential in order to avoid the doldrums and procrastination caused by unfinished voluble work ordered by a hegemonic writer.

Research Nutrition & Norepinephrine

I have had a colorful sedentary experience of hours otherwise.  I was online for an eternity to delve deeper into research for nutrition.  Then I researched the chemicals involved in the interaction with norepinephrine, which may help me to better understand the confusion that is whether I have a mental illness or a mental disorder.  

I purchased two books initially around 2:30am via an online transaction.  One of the books was a complete directory of food counts, which will help me choose foods higher in monounsaturated fats like olives, higher in fiber content than red kidney beans and low in cholesterol.  A book on how to use your genetic script to stay thin without dieting also captivated me.  So I purchased both these books via a secure site.

Then I rode on the trainer for a further twenty minutes.  I noticed the ride was easier than usual.  When I looked at the back wheel, I noticed the flywheel heated up and wore down the rubber on the back tire.  Shreds of rubber particles were littered all over the floor.  The tire had a flat spot now, but it never mattered much.

Research Cholecystokinin & Adrenaline Links

I researched metabolic pathways of biochemistry after this.  I became absorbed in the new buzzword cholecystokinin, which Alprazolam is highly effective in treating cholecystokinin related anxiety-panic disorders.  

I evolve in objective beliefs every couple of months, where I came to discover anxieties years back to schizophrenia, to adrenaline rushes, to norepinephrine, and now to cholecystokinin.  I am confused by the parallels and synonymy of symptoms I experience.  It makes it hard to label my condition or find the mechanism that makes me anxious, but the deeper I delve with each study, the closer I am to an answer.  With cholecystokinin, I feel like I am at the frontier of study.

I researched cholecystokinin for hours and received conflicting rationales and definitions of its composition and processes.  There are many conflicting studies online, but the general consensus I have been able to ascertain is that cholecystokinin is a neurological peptide, where a peptide is a compound containing two or more amino acids in which the carboxyl group of one acid is linked to the amino group of the other.  The function of the peptide however is discrepant in the scientific field, where some say it is a neurotransmitter while others argue it may be a neuromodulator.

Cholecystokinin in general consensus is an important gastrointestinal hormone.  Cholecystokinin is an endocrine peptide, which means it is secreted internally into the blood or lymph, particularly in the small intestine and in central and peripheral neurons.  Intestinal cholecystokinin is involved in the release of pancreatic enzymes and the contraction of the gallbladder while cerebral cholecystokinin is implicated in a variety of functions, such as behavior, anxiety and memory.  

Under the premise that cholecystokinin is an important neurotransmitter in the central nervous system, it is proposed it influences anxiety and dopamine related behavior, coexists with, and interacts with dopamine.  

Some also propose that as a neurotransmitter, it modulates the action of other neurotransmitters like dopamine, gamma-amino butyric acid and excitatory amino acids.  It is also said to modulate hypothalamic-pituitary-adrenal axis activity, where the hypothalamus is a region of the brain that is the regulating center for visceral functions, like sleep, body temperature and activity of the pituitary gland.  It would explain why moderation of these functions via cerebral cholecystokinin could affect all hormonal functions of the body.

The Distribution Of Cholecystokinin In The Body

Cholecystokinin is distributed in several regions of the brain including the cerebral cortex, hippocampus, amygdala nuclei and the hypothalamus.  It was first isolated as a thirty-three amino acid intestinal peptide hormone, which binds saturably and reversibly to distinct receptors in brain and pancreatic cell membranes.  

In both the brain and intestine, cholecystokinin exists in a number of molecular forms, of which the cholecystokinin octapeptide represents the most abundant species.

Two types of cholecystokinin receptors have also been identified, where one is involved in satiety of food intake and behavior while the other is involved with anxiety.  Major biological reactions of cholecystokinin are the reduction of food intake and the induction of anxiety-related behavior.  There is mounting evidence that aberrations in expression of cholecystokinin or its receptor within the human brain may play a part in the pathogenesis of certain types of anxiety and schizophrenia, where pathogenesis is the production and development of disease.

Some studies on mice conclude that while morphine induces a potent anxiolytic-like action (meaning to relieve anxiety), cholecystokinin when inserted acts as an endogenous antagonist of this anxiolytic-like effect of morphine.  The results all require closer scrutiny, but there seems to be a link made between cholecystokinin and panic-anxiety disorders.

I researched nonetheless until 7:30am, which is when my eyes did literally close.  

I was in overdrive with the computer dictionary to clarify definitions of this alien scientific vocabulary.  

I believe you will probably seek one as well, but for now, the hypnotic work on cholecystokinin is done.

Mumbles Visits Me

I had hoped for a well-deserved sleep, but instead I was woken up today at noon when I heard a motorbike out the front of my bedroom window.  I assumed it would be Almond but instead it was Mumbles.  In boxer shorts, I welcomed him into the house.  

I usually dread when people wake me up because I am unable to use Alprazolam to calm the mental disorder, so I was free of the chemical agonist to norepinephrine.  Nevertheless, I had a successful half hour with him because I was able to cope, function and behave in a normal non-erratic way.

“Hey.  Do you want to come see my new apartment tonight,” Mumbles invited me.

“Yeah, okay,” I said, despite how I knew it would cost money, and that money would probably make my purchase of two books online bounce.  

“You have to stay.  Come in,” I urged Mumbles, who was too impetuous to leave.

He sat down on my clerical chair.  As I turned on my new heater to warm the room, he complimented the new office area.  

“Come outside to the backyard.  Have a look at the new bench press I bought,” I showed Mumbles the bench press while he was here.  

He looked surprised by the new addition carport extension.

Mumbles mentioned his weekend.

“What happened at the birthday party last weekend,” I asked Mumbles, since he had mentioned it.

“I left after you all drifted off to sleep.  I was going to have tequila, but I had to drive, so I downed three beers instead,” he said.

Surf The Internet With Mumbles

I then dialed up access to the Internet and showed Mumbles the sites I had visited about nutrition, the citric acid cycle, articles about adenosine triphosphate and the books I had purchased.  

“You should join my course,” he said, “you would have so much fun.”  

“Nah,” I declined, “I would be unable to handle the class crowd.”  

“You will be with me,” he said, “or you can be alone.”

But even while I feel like I have rehabilitated in the battle to beat my mental illness (or disorder), it is too premature to run the anxious risk of a stressor like class.  

“You can do a correspondence course,” Mumbles suggested.

He could see how interested I was on the subject, but all my information is online, which is selective.  But ever since yesterday, I have started to compile a book of facts that I will have in print for reference soon.

Mumbles was an assisted endorphin release.  Half an hour later after some conversation over music, he left on his motorbike.  I made plans to visit him around 7pm today.  I may walk there or ride the racer, which depends on how much I drink.  

I nevertheless visited the local shops around 12:30pm to purchase another guarana drink.  I withdrew twenty dollars from my credit card for the possibility of alcohol.  So, the synergy of favorable biorhythm cycles and a social to assist emotional momentum is how this month has started on a more prosperous note.  

I will now revise contemporary revisions for an hour or so like said.  Then I will prepare to see Mumbles and Finn at their new residence.  I may come home tomorrow, but at least the writer has prepared and is at the forefront of his work, to allow alternative opportunities for resolutions.